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Returning appetite does not mean semaglutide is failingit reflects normal receptor adaptation seen in clinical trials

Similarly, a study of Reddit users' self-reported side effects of retatrutide differed markedly from clinical trial data, including increased appetite, food cravings, and insomnia

Topf is an assistant clinical professor of medicine at Oakland University William Beaumont School of Medicine, creator and host of the Freely Filtered and Channel Your Enthusiasm podcasts, creator of the Precious Bodily Fluids blog, and co-creator of NephMadness and NephJC

It is part of a group of drugs called GLP-1 receptor agonists