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Aging Cell 15 , 11261131 (2016)

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

Trends Pharmacol Sci

Notably, LPS-CD14 binding via pattern recognition receptors not only mediates innate immune activation but has been mechanistically linked to insulin resistance, obesity, and DM pathogenesis ( From a systems biology perspective, gut microbial metabolites serve as critical signaling mediators in gut-lung axis crosstalk, whose homeostatic disruption may reprogram metabolic-immune networks to propagate diabetic multi-organ complications

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