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Consequently, IGF-1 LR3 has improved biological potency and extended half-life

Over time, obese patients lose roughly 12% of their body weight on Wegovy (semaglutide) and about 18% on Zepbound (tirzepatide, which targets GLP-1 and another gut hormone, GIP.) Diana Thiara, MD, medical director of the UCSF Weight Management Program, says the results can be amazing and life-changing for people with obesity, a condition linked to a host of health risks

If both are being used primarily for weight loss, your prescriber may discuss whether combination therapy is necessary or whether optimising one medication first would be more appropriate