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Higher doses were required in titrate-to-target studies to achieve glucose control similar to Lantus

Isotopologue ratios from our [U- 13 C]glucose tracing experiments are consistent with SAAR increasing TCA cycle anaplerosis through PC (i.e., the generation of OAA from pyruvate) and the resulting OAA being preferentially directed to asparagine rather than flux through the TCA cycle

44 SuhN.JedamzikB.EckmannC

Neurologist 17 , S54S66 (2011)

This conservation is not surprising as oxidative stress is an inevitable byproduct of aerobic respiration, and GSH is an important antioxidant that mitigates the effects of reactive oxygen species (ROS), such as hydrogen peroxide