Motivated by the biological activity of halogenated peptidic natural products and the highly desirable chemoenzymatic access to halogenated peptidic intermediates, the activity of halogenating enzymeshalogenasesis gathering contemporary interest [18,19,20,21]
This is the single biggest mismatch between expectation and evidence, and it's worth revisiting even after reading the section above
In ovarian cancer cells, QUE enhanced the CIS sensitivity of the CIS-resistant cell line SKOV-3/CIS by inhibiting the expression of SOD2, catalase (CAT), GPX1, HO-1, Nrf 2, and PI3K/Akt/mTOR (62)
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