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In mouse and human islets, the insulinotropic effect of dihydrotestosterone depends on GLP-1R activation, and dihydrotestosterone amplifies the incretin effect of GLP-1 (48)

So there was some weight regain, about 5.7 pounds on average, but dramatically less than the 20 pounds regained by the placebo group

Although a more recent ICOP 2020 taxonomy existsand a recent systematic review found no material clinical or epidemiologic differences versus ICHD-IIIwe based enrollment on ICHD-III to preserve continuity and comparability 23,24

Laurie Rothman, a physician with Tampa General Hospital Concierge Health in Palm Beach Gardens

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