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Each domain is assessed using questions with an overall evaluation of low risk, some concerns, or high risk of bias

5.4 Other modulators of cGAS-STING signaling pathway Additional modulators primarily target the downstream signaling of cGAS-STING signaling pathway, and some of them have been studied in animal models

GLP-1 agents have a superior long-term safety profile for most patients

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Regarding hospitalization for heart failure, the HR was 0.83 (95% CI 0.671.04) for those under 65 years of age and 0.62 (95% CI 0.510.76) for those aged 65 years or older ( p interaction = 0.06), 0.72 (95% CI 0.610.84) for those under 75 years and 0.64 (95% CI 0.361.12) for those aged 75 years or older ( p interaction = 0.70), with no evidence of reduced efficacy in older patients