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Furthermore, safety data were collected using different methods, such as check boxes questionnaires, open format questionnaires, or verbal questioning, which may also have contributed to heterogeneity across safety outcomes

Follow-up was representative of real-world practice

Hormonal context also matters deeply for both men and women on these medications

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What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes