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The SELECT Trial: Design and Key Findings The SELECT trial enrolled 17,604 patients aged 45 or older with a BMI of 27 or greater and established cardiovascular disease (prior heart attack, stroke, or symptomatic peripheral artery disease), but critically, none had diabetes .[1] This design was intentionalresearchers wanted to understand whether semaglutide's cardiovascular benefits extended beyond its known effects in diabetic populations

Wadden TA, Chao AM, Machineni S, et al

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New England Journal of Medicine , 354 (22), 2340-2348