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As the melanocortin system has been linked to preference for fat intake ( The enhanced response in rats on the fcHF diet might also have been due to alterations in endogenous melanocortin signaling as a result of diet exposure ( The fcHFHS diet represents several features of the human obesity situation including increased fat mass, insulin resistance and peripheral leptin resistance compared to rats on the CHOW, fcHF, and fcHF diet ( Conclusion Rather than the level of obesity, is the composition of the diet, in particular the fat content, important in the feeding responses of the melanocortin system

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