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To generate analogs of 288 , the pericyclase EupF from the BGC of 288 , which uses 454 to catalyze intermolecular hetero-Diels-Alder cyclization, was replaced with AsR5 from the BGC of 38 , which accepts 39

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Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects