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A short explainer can also help you think through the distinction: When tiredness may not be routine at all There's another layer to this question

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After discarding the supernatant, the cell pellet was resuspended in 4 mL of erythrocyte lysis buffer and allowed to stand for 3 min to lyse erythrocytes

These data highlight the importance of sustained therapy or transition strategies (e.g., tapering, lifestyle reinforcement, or switching to maintenance agents) to prevent rapid rebound after treatment discontinuation

doi: 10.1530/eje-19-0171 50 NauckMAHeimesaatMMBehleKHolstJJNauckMSRitzelRet al