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In a healthy individual, eating a standard meal provides enough amino acids to trigger the mTORC1 pathway and stimulate muscle protein synthesis

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This indicates that CGRP can trigger CSD, possibly by initiating interactive processes between ascending cephalic pain pathways and CSD-susceptible areas, such as the visual cortex

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More physiologically relevant models, such as induced pluripotent stem cell-derived RPE (iPSC-RPE) and precision animal models, could help better mimic the progression of AMD and DR, thereby improving the translatability of preclinical findings