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(PubMed) Michels KB, Holmberg L, Bergkvist L, Ljung H, Bruce A, Wolk A

Sublingual absorption of large peptides is inherently variable because it depends on factors like sublingual blood flow, saliva production, mucosal integrity, and even how much the user moves their tongue during the holding period

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This new report does not negate those benefits but adds a layer of necessary nuance to their safety profile