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In the context of hepatic lipid metabolism, the equilibrium between cholesterol and bile salt excretion within bile serves as a preventive mechanism against the formation of biliary crystals [29]

Real-world adherence is substantially lower than clinical-trial completion rates, with persistence estimates ranging from approximately one-third to one-half at 1 year and substantially lower by 2 years in many analyses

10.1097/CJI.0b013e3181f1d614 138 SunH.CaiH.XuC.ZhaiH.LuxF.XieY.et al (2022)

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Their main action consists of inhibiting the cholesterol biosynthesis pathway