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Pre-Existing Conditions Not all patients are equally vulnerable

Potential therapies Although some researchers have attempted to establish a treatment for ME/CFS and no reproducible results have been found (60), some treatments seem promising in ME/CFS ( Figure 13 )

Therefore, localized immunometabolic disturbances, particularly defective butyrate metabolism and dysregulated tryptophan catabolism, disrupt the Th17/Treg balance and compromise epithelial integrity in IBD, underscoring the gut microbiome and microbial metabolites as actionable therapeutic targets

There was strong consensus in favor of NBS for HT-1, using blood succinylacetone as a marker, followed by diagnostic confirmation and early treatment with NTBC and diet