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Furthermore, NO increases blood flow by relaxing the smooth vascular muscle and abdominal, and central obesity leads to an imbalanced production of fat-derived metabolic products, hormones, and adipokines that predispose to a state endothelial dysfunction, activating NADPH oxidase [67]

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BPC-157's therapeutic window is wide but flat

And without that stimulus, the body has even less reason to preserve muscle tissue during weight loss