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In models of moderate ethanol exposure superimposed with CCl 4 characterized by activated HSCs, the expression and nuclear localization of -catenin and YAP expression was increased by ethanol

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At 36 weeks, concomitant IXE plus TIR met the primary and all key secondary endpoints for superiority against IXE monotherapy

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The most frequently reported adverse events were gastrointestinal in nature, including nausea (occurring in 25-33% of patients), diarrhea, vomiting, constipation, and abdominal discomfort