Introduction Physicians are adapting to a new era in healthcare brought about by the Covid-19 pandemic.[1] Among the myriad of challenges faced is the management of patients for whom Covid-19 risk is elevated, especially given the epidemiological evidence that diabetes and cardiovascular disease are major risk factors for severe Covid-19 and mortality.[2][13]
In agreement with KYN and NO level plasma lactate is significantly elevated in the OVX animals compared to control and this was reversed by E2 administration, further indicating systemic inflammation induced by estrogen-deprivation and its mitigation in presence of estrogen (Figs
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