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We proposed to apply this modified approach in determining ACOs' participation options for new agreement periods beginning on or after January 1, 2027, and we believe this proposed timing of applicability provides currently participating ACOs sufficient time to strategize the operational changes necessary to support their transition to performance-based risk

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Many eukaryotic proteins are produced as inclusion bodies (insoluble aggregated protein), a malfunctioning protein caused by misfolding, in prokaryotic expression systems such as E