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50 However, two phase 3 trials of selonsertib (an ASK-1 inhibitor) were terminated early due to a lack of efficacy in MASH adults with stage 3 (NCT03053050) and stage 4 (NCT03053063) fibrosis

Common initial side effects include nausea, vomiting, diarrhea, and reduced appetitemost of which decrease as your body adjusts

Disclosed on slide 19 of the Q4 2025 earnings deck under Phase 3 Initiations

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One important and underappreciated contributor may be ammonia, especially when gut dysbiosis, altered urea cycle handling, or poor mitochondrial function are present