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Some compounded formulations already include B12, like semaglutide with B12 and tirzepatide with B12 , which simplifies the supplementation process

A clinical trial investigated the effect of 8-week metformin treatment on aging individuals with mild cognitive impairment (MCI) or early AD, and the results revealed that metformin is associated with improved executive function, companied by improvement in learning/memory and attention [27]

doi: 10.2337/db24-1668-P

In addition to its effects on appetite and weight loss, Semaglutide GLP-1 also stimulates the production of insulin in response to food intake, which helps to lower blood sugar levels

The steep weight loss and significant cardiovascular and metabolic benefits associated with drugs like semaglutide and tirzepatide underlie their rapid rise in popularity