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Nevertheless, understanding GI adverse events across both earlier and newer GLP-1based therapies remains highly relevant, particularly as these agents are increasingly prescribed for long-term and off-label indications

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SGLT2 inhibitors, such as empagliflozin and canagliflozin, have similar A1C-lowering properties (0.5%-0.8%) and out-of-pocket costs (except for alogliptin, which is available generically), but have the added advantages of CV risk reduction, BP-lowering, and weight loss

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At doses above 3,000 mg daily, L-carnitine side effects become more common