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Harris and his multidisciplinary team remain committed to translating these insights from the laboratory bench to clinical application, aiming to develop targeted therapies that impair tumor metabolism while preserving normal tissue function, ultimately improving survival rates and quality of life for cancer patients

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A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)