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A change in diabetes drug prescribing led to clinical trials of intranasal insulin administration, followed by insulin sensitizers, including metformin and peroxisome proliferator-activated receptor agonists, followed by incretin mimetics targeting primarily GLP-1R (GLP-1RAs) [106]
Cucumbers are really a good example
Common causes include postherpetic neuralgia, diabetic neuropathy, and peripheral nerve injury 1
Take home points: Empagliflozin has a large study that shows a small but significant reduction in death and heart failure hospitalizations (NNT for primary outcome = 63 patients for ~3 years) compared to placebo in patients with diabetes and CV disease Empagliflozin can cause urinary and genital infections and ketoacidosis with near normal glucose Because of its mechanism (spilling glucose through the urine), it may develop a role in diabetes mellitus type 1 Refrences: American Diabetes Association: Standards of medical care in diabetes - 2016