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The Standards of Medical Care in Diabetes, updated annually, includes dedicated sections on incretin-based therapies relevant for understanding tirzepatide pharmacology and clinical application

Activation of the GLP-1 receptor initiates a series of cascading reactions, which exert a hypoglycemic effect by stimulating insulin secretion from pancreatic -cells and inhibiting glucagon secretion from -cells, thereby reducing the stimulatory effect of glucagon on gluconeogenesis in the liver (Figure 2)

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Monitor Your Health Pay close attention to your bodys reactions when combining semaglutide with other medications