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In clinical trials, diarrhea was reported by approximately 20 to 30% of participants taking semaglutide or tirzepatide

At the same time, caution is warranted in patients with current or previous eating disorders or psychiatric comorbidity, because GLP-1RAs may theoretically improve, maintain, or worsen eating-disorder symptoms depending on the individual context (108)

Most people if they have not addressed the underlying cause of the weight gain will gain the weight back

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However, this does not definitively exclude the possibility of muscle-related symptoms in individual patients, as clinical trials may not capture all real-world experiences, particularly uncommon or delayed adverse effects