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Clinical data shows that switching to dual-agonist therapy often produces additional weight loss of 510% of starting body weight in previously plateaued patients

Hepatic fat content dropped dramatically a benefit largely attributed to glucagon receptor activation, which directly stimulates hepatic lipid oxidation and reduces lipogenesis

10.1016/j.physbeh.2011.12.001 23 Di ChiaraG

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Patients should never stop or adjust their medication without first consulting the prescribing clinician or trial investigator, as abrupt discontinuation may affect metabolic control and overall health outcomes