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Abstract Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging and anti-inflammatory responses

In particular, they stated -Lipoic acid, and even more so its dihydro derivative to which it is rapidly converted after entering cellular metabolism, could act as an antioxidant for ascorbic acid and tocopherols

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Sublingual Routes Oral medications often face challenges related to first-pass metabolism, where much of the drug is metabolized in the liver before reaching systemic circulation