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Semaglutide was extensively tested in several phase 3 trials for its therapeutic potential, including as part of the Semaglutide Treatment Effect in People with Obesity (STEP) and Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical programs

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The clinical relevance of Wegovy reflects the convergence of three highburden conditionsobesity, cardiovascular disease, and metabolic liver diseasewhere weight reduction and metabolic improvement can modify longterm outcomes but where durable, nonsurgical options have historically been limited

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RA T cells exhibit reduced respiratory capacity and abnormal mitochondrial dynamics influenced by microRNAs such as miR-125b, which regulates the mitochondrial fission protein MTP18