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These cells become detectable in vitro within the outer retinal layers and choroid, where they are typically rare or absent (Figure 3) [89]

While the benefits of supplementation in the general population remain uncertain, there is a growing body of evidence suggesting it plays a critical role in healthparticularly for those at risk of deficiency, including pregnant individuals, vegans, and older adults

What this means practically Two important caveats

3) Common pathophysiological mechanisms involving impaired SCFA production, immune-inflammatory activation, and dysregulated neuroactive metabolite metabolism

Betaine is an osmolyte that regulates cell volume and protect cell integrity against osmotic stress (especially in the kidney)