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CYP2D6 is responsible for the metabolism of more than 100 pharmaceuticals, and a polymorphism of this enzyme is responsible for the long-established variation in the metabolism of debrisoquine, mentioned above

Doctors vehemently recommend against doing this without medical supervision

In ALS, there is an abnormal cytoplasmic aggregation of misfolded proteins, mainly DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS) (Wijesekera and Leigh 2009)