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Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest

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Furthermore, lixisenatide was associated with a reduced risk of new-onset macroalbuminuria when adjusted for baseline HbA1c [hazard ratio, 0.81 (95% confidence interval 0.660.99

Tirzepatide, on the other hand, is usually initiated at 2.5 mg weekly and can be titrated (adjusted gradually) up to 15 mg weekly