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Those with documented deficiency in B12, B1, or B6 Patients with peripheral neuropathy (tingling, numbness, burning extremities) Those with lower back pain and sciatica with a neurological component Diabetic patients especially those on metformin (B12 depletion) Strict vegans the only people with complete B12 dietary absence Elderly adults with impaired B12 absorption Post-gastric or intestinal surgery patients Who Should Use with Caution

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Because the immune system is the major trigger of skin conditions like psoriasis, glutathione both helps prevent the problem as well as fix it once it has occurred

While manageable in the short term, these challenges can gradually erode adherence, making long-term use difficult even for those who initially respond well