While the exact mechanism is not fully understood, it is believed that the medications impact on the bodys metabolism and endocrine system could play a role
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The commenter stated that implementing a waiver process for such drugs would incentivize manufacturers to improve supply and resolve the shortage more quickly compared to current policy described in subpart E of part 427
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Specifically, the FDA is requiring Lilly to complete various post-marketing clinical trials of Foundayo to look at the potential risks for various side effects, including cardiovascular events, liver toxicity, and delayed gastric emptying (gastroparesis), as non-clinical or observational studies will not be sufficient