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This activation occurs through a mechanism distinct from SSRIs, potentially explaining why TREK-1 channel blockers may help people who do not respond to conventional serotonin-based treatments

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Mendona R, Silveira AA, Conran N

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In biochemical and cellular research models, BPC-157 has been reported to interact with multiple signalling pathways, including nitric oxideassociated mechanisms, growth factor-related signalling, and cytoskeletal regulatory processes