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A systematic review of 35 studies found consistent age-related GSH decline in blood and specific brain regions, including the precuneus, hippocampus, cingulate, and frontal cortex

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Exploratory subgroup analysis of the whole cohort showed similar overall trends in benefits in rates of acute healthcare utilization, all-cause mortality, and CKD progression but not combined cardiovascular composite event outcome within the GLP1-RA group compared to DPP4i group, although there was treatment effect heterogeneity between several subgroups (Supplementary Fig

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