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While several studies have evaluated probiotic use for 4 to 6 weeks, few have extended supplementation over several months or more, which may be necessary to observe long-term effects, particularly in elite athletes or aging populations

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The overall safety profile appears favorable based on available data, though individual responses vary

Single missed doses have minimal impact on cumulative results

Studies have even shown that having an older appearance, especially in women, is associated with discrimination in the workplace