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In Phase 3 clinical trials completed in December 2025, retatrutide produced an average body weight reduction of 28.7% at the highest dose over 68 weeks

American Journal of Biomedical Science & Research , 15 (2), 153

Also, women in midlife may have other health concerns alongside weight, such as bone health, cardiovascular health, and loss of muscle, which could affect how they respond to GLP-1s