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Doctors stress early detection and treatment

While semaglutide pharmacokinetics are not significantly altered in patients with hepatic impairment, the medication has not been extensively studied in patients with severe hepatic dysfunction

Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects

The peptide reduces myofibroblast differentiation by downregulating -smooth muscle actin (-SMA) and collagen type I alpha 1 (Col1a1) expression, key markers of activated fibroblasts