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This limitation is expected to be addressed by a dedicated two-phased validation strategy in future work: Phase I Retrospective RNA Validation: This involves prioritizing an intensive search for and inclusion of any suitable independent external RNA-seq cohorts with adequate clinical follow-up data

Finally, to examine the effect of intermittent or continuous GLP-1R receptor stimulation, the impact of genotype was characterized for both short and long-acting agonists, data from all 5 studies were pooled (Additional file 2: Fig

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The most commonly reported adverse events were gastrointestinal disorders and hypoglycemia in patients with type 2 diabetes concurrently using sulfonylureas, metformin, and/or SGLT-2 inhibitors