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Thats because a 500mg dose of powder amounts to 439mg of berberine, which doesnt exactly align with a clinical dose

Full mechanistic coverage is in the mitochondrial peptides research overview

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Furthermore, syringic acid administration has been linked to the amelioration of cardiac ischemia-reperfusion injury in the rat model, by blocking mitochondria-induced apoptosis that is controlled by the PI3K/Akt/GSK-3 signaling pathway [25, 26]