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A phase I study (NCT03458117) was conducted for the evaluation of effectiveness, safety, and tolerability after repeated T-VEC injections in patients with non-melanoma skin cancer [211]

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Additionally, IL-6 can be secreted by FLSs and B cells in the RA synovium and has been closely linked to the pathogenesis of the disease [236]

Concurrently, it interferes with noncanonical pathways, including the Wnt/-catenin and NF-B pathways, thereby maintaining epithelial cell polarity and structural integrity and suppressing EMT and ECM deposition (35)

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