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Disruption of Normal Tissue Function Senescent cells play a role in repair and regeneration of some tissues

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2019) stimulated mouse-derived NSPCs with different concentrations of G1, a selective GPER-1 agonist, showed a dose-dependent decreased proliferation, which was blocked by selectively inhibiting GPER-1

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The study also reported upregulated gene expression of MMP1 and MMP2, which facilitate the removal of damaged collagen, enabling the formation of new, healthy fibers