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One of the most widely recognized extrahepatic manifestations of Wilsons disease is the characteristic KayserFleischer (K-F) ring in the ocular cornea21 (Figure 253)

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Studies have found that DES IGF-1 binds IGF-1R with 210 times higher affinity than the native sequence in direct binding assays (Carlsson-Skwirut et al., 1989)

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As discussed in the FY 2021 rulemaking, Berenson et al

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