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These were ex-vivo permeation experiments framed around anti-inflammatory delivery rather than wrinkle outcomes, so they speak to whether the molecule can reach the dermis, not to how much cosmetic change follows but even that limited, mechanism-level demonstration is one the injectable route has no equivalent of for reaching skin specifically

Its plasma concentration decreases with age (200 ng/mL at age 20 vs

However, your metabolism will be even higher if you have a significant amount of muscle mass