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According to NICE guideline NG28 on type 2 diabetes management and the specific NICE Technology Appraisal for tirzepatide, GLP-1 receptor agonists like Mounjaro may be considered as part of a comprehensive treatment strategy when glycaemic targets are not achieved with other therapies or when weight loss would provide significant clinical benefit

I would not be surprised if SUD eventually became a clinical indication for using a GLP-1. Lacking that, DeRoo said that the ideal patients who can benefit from GLP-1 off-label uses across mental health are those who already meet clinical criteria to receive a prescription for a GLP-1

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[3] Karakasis P, et al