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In VRK2-KO cells, most of cells displayed ER distribution of SLC7A11 regardless of monensin addition or removal, suggesting that VRK2 did not have an influence on Golgi-to-PM trafficking of SLC7A11 (Fig

Oral bioavailability studies in rats show systemic effects even when administered per os, suggesting meaningful absorption through the GI mucosa

Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J, Mackinnon AL, Parlati F, Rodriguez ML, Shwonek PJ, Sjogren EB, Stanton TF, Wang T, Yang J, Zhao F, Bennett MK

Continuing causes genuine damage

NCTC1469 cells, a normal mouse hepatocyte cell line, were obtained from the American Type Culture Collection and were cultured in DMEM containing 10% (v/v) fetal horse serum, 2 mM glutamine, 5 U/mL penicillin, and 50 g/mL streptomycin at 37 C in a humidified O 2 /CO 2 (19:1) atmosphere