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46 showed that a preserved responsiveness to the endothelium-dependent vasodilator acetylcholine, administered intracoronarily, is associated with a significantly lower incidence of cardiovascular events defined as a composite end point, including cardiovascular death, unstable angina, myocardial infarction, coronary revascularization, ischemic stroke and peripheral artery revascularization

Rinkevich, B., Mller, W

This is more likely if you are not drinking enough water or eating a balanced diet daily