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Maximally tolerated doses of background therapy were to remain unchanged for the duration of the trial

Clinical trials have demonstrated that tirzepatide can reduce hemoglobin A1c by up to 2.5% in type 2 diabetes, with weight loss typically ranging from 5-10% in diabetes patients and 15-20% in those treated specifically for obesity

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Researchers chose other diabetes drugs as the comparison, rather than people on nothing, since patients starting any of these drugs tend to look similar health-wise, then used statistics to smooth out remaining differences, like GLP-1 starters being younger and heavier on average